内容简介
本研究论文设计、制造了一种新型骨增量装置并对其进行安全性验证。对于有严重骨缺损的患者，使用商业产品如髋臼杯和衬垫进行全髋关节置换手术，失败的可能性很大。对于这些患者，单靠髋臼杯不能覆盖骨缺损处，因此需要额外的骨增量装置或固定支架。本研究设计了可三维（3D）打印的骨增量装置，作为使用固定支架手术的替代方案。该增量装置具有双孔结构，以减轻整体重量并促进骨生长，同时利用两种框架来防止对多孔结构的损害，并在打印过程中保持整体稳定性。此外还设计了两种类型的孔，以便在不同角度固定假体。本研究3D打印了35个不同大小的具有尖锐边缘的骨增量装置，并对有限元分析结果最不理想的试样进行疲劳测试，结果证实了试样在5340 N载荷下的结构稳定性。在实验中测得试样的孔隙率为63.70%，但孔隙率测试是局部随机进行的，因此不能证明孔隙率是均匀分布的。综上所述，本研究提出了能够通过成角螺丝孔和底面螺丝孔双向和不同角度进行连接的3D打印双孔骨增量装置。该装置的力学试验结果表明其结构安全性良好。然而，更深入的研究该装置的临床应用依然是必要的。
文章导读
图1 髋增量装置设计：(a)增量装置形状；(b)锋利边缘；(c)平滑边缘
图2 (a)内圆边框架；(b)外圆边框架
图3 双孔接触点处的薄壁框架
图4 增量装置：(a)外径；(b)厚度
图5 (a)外部不规则结构；(b)内部规则结构
参考文献
上下滑动以阅览
2. Amstutz HC (1991) Hip arthroplasty. Churchill Livingstone, New York
3. Van HJ, Khanduja V, Pattyn C et al (2017) The history of biomechanics in total hip arthroplasty. Indian J Orthop 51(4):359–367. https://doi.org/10.4103/ortho.IJOrtho_280_17
4. Kim SM, Kim Y (2019) National health insurance statistical yearbook. Published by Health Insurance Review & Assessment Service, National Health Insurance Service. ISSN 1738–8945 (in Korean)
5. Steiner C, Andrews R, Barrett M, et al (2012) HCUP projections report (2012-03). U.S. Agency for Healthcare Research and Quality, Rockville
7. Alejandro Gonzalez Della Valle, MD (2016) Revision total hip replacement: an overview. Hospital for Special Surgery. https://www.hss.edu/conditions_revision-total-hip-replacement-overview.asp
8. Kim HJ, Kim JS, Han SM et al (2009) Evaluation of mechanical stability in development of customized hip implant. J Kor Soc Precis Eng 26(7):31–37 (in Korean)
10. Dearborn JT, Harris WH (2000) Acetabular revision arthroplasty using so-called jumbo cementless components: an average 7-year follow-up study. J Arthroplasty 15(1):8–15. https://doi.org/10.1016/s0883-5403(00)90999-9
11. Tsai SW, Chen CF, Wu PK et al (2018) Cement augmentation in the proximal femur to prevent stem subsidence in revision hip arthroplasty with Paprosky type II/IIIa defects. J Chin Med Assoc 81(6):571–576. https://doi.org/10.1016/j.jcma.2017.11.008
15. Migaud H, Common H, Girard J et al (2019) Acetabular reconstruction using porous metallic material in complex revision total hip arthroplasty: a systematic review. Orthop Traumatol Surg Res 105(1):S53–S61. https://doi.org/10.1016/j.otsr.2018.04.030
19. Woo SH, Sung MJ, Park KS et al (2020) Three-dimensional-printing technology in hip and pelvic surgery: current landscape. Hip Pelvis 32(1):1–10. https://doi.org/10.5371/hp.2020.32.1.1
21. Wang Z, Wang C, Li C et al (2017) Analysis of factors influencing bone ingrowth into three-dimensional printed porous metal scaffolds: a review. J Alloys Compd 717:271–285. https://doi.org/10.1016/j.jallcom.2017.05.079
24. Sporer SM, Paprosky WG (2006) The use of a trabecular metal acetabular component and trabecular metal augment for severe acetabular defects. J Arthroplasty 21(6):83–86. https://doi.org/10.1016/j.arth.2006.05.008
25. Kienapfel H, Sprey C, Wilke A et al (1999) Implant fixation by bone ingrowth. J Arthroplasty 14(3):355–368. https://doi.org/10.1016/s0883-5403(99)90063-3
26. ASTM F1854-15 (2016) Standard test method for stereological evaluation of porous coatings on medical implants. ASTM International, West Conshohocken
28. Fuchs J, Ron M, Liepins I et al (2011) In vitro test model for evaluating fatigue performance for acetabular wedge augment device. ORS annual meeting. Poster No. 991
29. Anovitz LM, Cole DR (2015) Characterization and analysis of porosity and pore structures. Rev Mineral Geochem 80(1):61–164. https://doi.org/10.2138/rmg.2015.80.04
30. Arabnejad S, Johnston RB, Pura JA et al (2016) High-strength porous biomaterials for bone replacement: a strategy to assess the interplay between cell morphology, mechanical properties, bone ingrowth and manufacturing constraints. Acta Biomater 30:345–356. https://doi.org/10.1016/j.actbio.2015.10.048
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Bio-Design and Manufacturing（中文名《生物设计与制造》），简称BDM，是浙江大学主办的专业英文季刊，主编杨华勇院士、崔占峰院士，2018年新创，目前已被SCI-E等检索，最新影响因子为5.887。
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